Principal Scientist – Discovery Oncology

About the role

The Principal Scientist in Discovery Oncology will lead pre‑clinical research within Roche’s Cancer Cell Dependencies unit, translating basic findings into therapeutic strategies for cancer.

Key responsibilities

• Lead internal target identification initiatives from ideation to program nomination.
• Design, execute and interpret experimental strategies, integrating high‑dimensional ‘omic’ data for target validation.
• Coordinate global cross‑functional portfolio projects as a matrix leader.
• Provide clear Go/No‑Go recommendations for assets across discovery stages and oversee material transfer agreement studies.

Required profile

• PhD or MD/PhD in Molecular/Cellular Biology, Immunology, Pharmacology or related field.
• Minimum 6 years of post‑doctoral experience in academia or industry, preferably in cancer drug discovery.
• Strong collaborative mindset and ability to work in a matrix organization.

Required skills

• Experience with genetic and pharmacological approaches to study target mechanisms.
• Knowledge of intracellular oncogenic signalling and cancer cell dependencies.
• Ability to work with high‑dimensional ‘omic’ datasets for target validation.