RNA Biology Associate – Oligonucleotide Screening

About the role

Roche is seeking an experienced Lab Associate to support molecular and RNA biology tasks within the Nucleic‑acid‑based medicines team. The role focuses on screening oligonucleotide‑based therapeutics and advancing RNA technologies.

Key responsibilities

• Develop and execute cell‑based screening assays, including cell culture maintenance.
• Implement lab automation for high‑throughput oligonucleotide screening.
• Purify and handle RNA samples; perform digital PCR and quantitative PCR (qPCR) assays.
• Prepare and process tissue samples from animal studies for molecular analyses.
• Assist in advanced molecular biology assays such as transcriptome profiling (DRUG‑Seq, BRB‑Seq, RNA‑Seq).

Required profile

• B.Sc. in molecular biology or related field with at least 10 years of drug discovery experience, or M.Sc. with at least 5 years.
• Hands‑on experience with therapeutic oligonucleotides, screening, and in‑vitro characterization.
• Strong organizational skills, attention to detail, and ability to work collaboratively.

Required skills

• Molecular biology and RNA biology techniques (qPCR, digital PCR).
• Lab automation and high‑throughput screening.
• Cell culture and tissue sample preparation.
• Transcriptome profiling methods (DRUG‑Seq, BRB‑Seq, RNA‑Seq).