Principal Scientist, Cryo-EM Structural Biology

About the role

Novartis is looking for a Principal Scientist / Senior Scientist in Cryogenic Electron Microscopy (Cryo-EM) Structural Biology within its Protein Sciences group in Discovery Sciences, based onsite in Basel, Switzerland. You will apply Cryo-EM to challenging targets in early drug discovery, working with scientists across Biomedical Research to prepare biological samples, generate and interpret high-quality structural data and turn molecular insights into actionable science.

Key responsibilities

• Contribute experimentally and scientifically to early drug-discovery projects within multidisciplinary teams.
• Prepare biological samples for Cryo-EM, including data collection, processing, structural determination and model building.
• Apply current Cryo-EM technologies and methodologies to generate high-quality structural insights for drug discovery.
• Mentor laboratory associates and provide technical training in a matrix environment.
• Maintain accurate experimental records, scientific documentation and instrument logs.
• Communicate findings through internal and external presentations and scientific publications.

Required profile

• PhD in a relevant scientific discipline with at least five years of research experience, or an equivalent combination of training and experience.
• Deep expertise in Cryo-EM, including sample preparation, single-particle analysis, structure determination, model building and structural interpretation.
• Hands-on experience operating high-end cryo-transmission electron microscopes.
• Demonstrated experience expressing and purifying a range of protein targets.
• Excellent written and spoken English, with strong scientific communication and presentation skills.
• Strong analytical skills, attention to detail and a collaborative approach in multidisciplinary teams.

Desirable requirements

• Troubleshooting and optimizing workflows for single-particle analysis and cryo-electron tomography.
• Familiarity with AI-based and computational tools for protein construct design and optimization.
• Experience characterizing protein-ligand interactions.
• Hands-on experience with single-particle analysis, cryo-electron tomography and dual-beam scanning electron microscopy.

What we offer

• Expected annual base salary range of CHF 93,800 to 174,200, set according to skills, competencies and experience.
• Possible performance-based bonus depending on performance parameters.
• Competitive benefits in kind such as insurance plans, retirement plans and wellbeing resources.
• Flexible and hybrid working options where possible, and at least 14 weeks of paid parental leave.